Профилактика и лечение канцер-ассоциированных тромбозов при проведении химиотерапии
https://doi.org/10.17650/3034-2473-2024-1-2-32-44
Аннотация
У пациентов со злокачественными новообразованиями частота возникновения симптомных венозных тромбоэмболических осложнений (ВТЭО) в 4–7 раз выше, чем в общей популяции. Наличие отдаленных метастазов при солидных опухолях повышает риск венозных тромбозов. Наиболее часто ВТЭО развиваются при раке поджелудочной железы и раке желудка. Химиотерапия увеличивает риск развития ВТЭО. Для их лечения при проведении химиотерапии используют низкомолекулярные гепарины и прямые оральные антикоагулянты. Перед началом химиотерапии необходимо оценить риск развития ВТЭО, используя шкалу Khorana. Амбулаторным пациентам с раком высокого риска (сумма баллов по шкале Khorana ≥3 до начала нового режима системной химиотерапии) может быть назначена профилактика ВТЭО.
Об авторах
И. А. Королева
ЧУОО ВО «Медицинский университет «Реавиз»
Россия
Россия
Ирина Альбертовна Королева
443001 Самара, ул. Чапаевская, 227
М. В. Копп
ЧУОО ВО «Медицинский университет «Реавиз»
Россия
Россия
443001 Самара, ул. Чапаевская, 227
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Рецензия
Для цитирования:
Королева И.А., Копп М.В. Профилактика и лечение канцер-ассоциированных тромбозов при проведении химиотерапии. Поддерживающая терапия в онкологии. 2024;1(2):32-44. https://doi.org/10.17650/3034-2473-2024-1-2-32-44
For citation:
Koroleva I.A., Kopp M.V. Prevention and treatment of cancer-associated thrombosis during chemotherapy. Supportive Therapy in Oncology. 2024;1(2):32-44. (In Russ.) https://doi.org/10.17650/3034-2473-2024-1-2-32-44
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