Preview

Supportive Therapy in Oncology

Advanced search

Study of the use of La Roche-Posay Dermatological Laboratory skincare products for radiodermatitis prevention and treatment

https://doi.org/10.17650/3034-2473-2024-1-2-14-22

Abstract

Risks of adverse effects during therapy increase along with progress in oncology and development of new treatment methods. Thus, radiotherapy, one of the main methods of treatment of malignant tumors of various locations, can cause radiodermatitis: an adverse side effect manifesting on the skin in the irradiated area or near it. Clinical manifestations vary from stage to stage and negatively affect patients’ willingness to undergo or continue treatment due to fear of esthetic defects of the skin. Additionally, development of advanced stage radiodermatitis carries the risk of infectious complications in this area. One of the goals of radiation therapists is management of radiation-induced dermatitis and search for techniques aimed at its treatment and prevention.

This study evaluates the effects of several products and their components on clinical manifestations of radiodermatitis caused by radiation therapy.

About the Authors

D. A. Balaeva
Central Clinical Hospital “RZD-Medicine”; Russian University of Medicine, Ministry of Health of Russia
Russian Federation

Dayana Arsenovna Balaeva

2 Budayskaya St., Moscow 129128

Build. 1, 20 Delegatskaya St., Moscow 127473



G. A. Garyaev
Central Clinical Hospital “RZD-Medicine”; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
Russian Federation

2 Budayskaya St., Moscow 129128

Build. 1, 2/1 Barrikadnaya St., Moscow 125993



M. D. Ter-Ovanesov
Russian University of Medicine, Ministry of Health of Russia
Russian Federation

Build. 1, 20 Delegatskaya St., Moscow 127473



D. S. Romanov
Central Clinical Hospital “RZD-Medicine”; Russian University of Medicine, Ministry of Health of Russia; Center for Innovative Medical Technologies
Russian Federation

2 Budayskaya St., Moscow 129128

Build. 1, 20 Delegatskaya St., Moscow 127473

22b Dukhovsky Lane, Moscow 115191



Yu. Yu. Gorchak
Russian University of Medicine, Ministry of Health of Russia
Russian Federation

Build. 1, 20 Delegatskaya St., Moscow 127473



References

1. Pelevina I.I., Petushkova V.V., Biryukov V.A. et al. The “radiation-induced non-targeted effects” and their role in human cell response to low radiation forcing. Radiatsionnaya biologiya. Radioekologiya = Radiation Biology. Radioecology 2019;59(3):261–73. (In Russ.). DOI: 10.1134/S086980311903010X

2. Schmeell L.C., Koch D., Stumpf S. et al. Prophylactically applied Hydrofilm polyurethane film dressings reduce radiation dermatitis in adjuvant radiation therapy of breast cancer patients. Acta Oncol 2018;57(7):908–15. DOI: 10.1080/0284186X.2018.1441542

3. Robijns J., Censabella S., Claes S. et al. Prevention of acute radiodermatitis by photobiomodulation: a randomized, placebo-controlled trial in breast cancer patients (TRANSDERmIS trial). Lasers Surg med 2018;50(7):763–71. DOI: 10.1002/lsm.22804

4. Sekiguchi K., Akahane K., Ogita M. et al. Efficacy of heparinoid moisturizer as a prophylactic agent for radiation dermatitis following radiotherapy after breast-conserving surgery: a randomized controlled trial. Jpn J Clin Oncol 2018;48(5):450–7. DOI: 10.1093/jjco/hyy045

5. Bontempo P.S.M., Ciol M.A., Menêses A.G. et al. Acute radiodermatitis in cancer patients: incidence and severity estimates. Rev Esc Enferm USP 2021;55:e03676. DOI: 10.1590/S1980-220X2019021703676

6. Cox J.D., Stetz J., Pajak T.F. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995;31(5):1341–6. DOI: 10.1016/0360-3016(95)00060-C

7. Chan R.J., Webster J., Chung B. et al. Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials. BmC Cancer 2014;14:53. DOI: 10.1186/1471-2407-14-53

8. Matsuu-Matsuyama M., Nakashima M., Shichijo K. et al. Basic fibroblast growth factor suppresses radiation-induced apoptosis and TP53 pathway in rat small intestine. Radiat Res 2010;174(1):52–61. DOI: 10.1667/RR1802.1

9. Roy I., Fortin A., Larochelle M. The impact of skin washing with water and soap during breast irradiation: a randomized study. Radiother Oncol 2001;58(3):333–9. DOI: 10.1016/s0167-8140(00)00322-4

10. Gilca M., Tiplica G.S., Salavastru C.m. Traditional and ethnobotanical dermatology practices in Romania and other Eastern European countries. Clin Dermatol 2018;36(3):338–52. DOI: 10.1016/j.clindermatol.2018.03.008

11. Messire G., Serreau R., Berteina-Raboin S. Antioxidant effects of catechins (EGCG), andrographolide, and curcuminoids compounds for skin protection, cosmetics, and dermatological uses: an update. Antioxidants (Basel) 2023;12(7):1317. DOI: 10.3390/antiox12071317

12. Boo Y.C. Mechanistic basis and clinical evidence for the applications of nicotinamide (niacinamide) to control skin aging and pigmentation. Antioxidants (Basel) 2021;10(8):1315. DOI: 10.3390/antiox10081315

13. Madaan P., Sikka P., Malik D.S. Cosmeceutical aptitudes of niacinamide: a review. Recent Adv Antiinfect Drug Discov 2021;16(3):196–208. DOI: 10.2174/2772434416666211129105629

14. Xie J., Jia L., Xie P. et al. Efficacy and safety of epigallocatechin-3-gallate in treatment acute severe dermatitis in patients with cancer receiving radiotherapy: a phase I clinical trial. Sci Rep 2023;13(1):13865. DOI: 10.1038/s41598-023-40881-4

15. Prades-Sagarra È., Yaromina A., Dubois L.J. Polyphenols as potential protectors against radiation-induced adverse effects in patients with thoracic cancer. Cancers (Basel) 2023;15(9):2412. DOI: 10.3390/cancers15092412

16. Mioc M., Milan A., Malița D. et al. Recent advances regarding the molecular mechanisms of triterpenic acids: a review (part I). Int J mol Sci 2022;23(14):7740. DOI: 10.3390/ijms23147740

17. Park H.A., Kim M.Y., Lee N.Y. et al. Variation of triterpenic acids in 12 wild Syzygium formosum and anti-inflammation activity on human keratinocyte HaCaT. Plants (Basel) 2021;10(11):2428. DOI: 10.3390/plants10112428

18. Shao X., Chen T., Li H. et al. Efficacy of topical steroids in preventing radiation dermatitis: a systematic review and meta-analysis. Dermatol Ther 2022;35(12):e15918. DOI: 10.1111/dth.15918

19. Tam S., Zhou G., Trombetta M. et al. Topical corticosteroids for the prevention of severe radiation dermatitis: a systematic review and meta-analysis. Support Care Cancer 2023;31(7):382. DOI: 10.1007/s00520-023-07820-5

20. Ho A.Y., Olm-Shipman M., Zhang Z. et al. A randomized trial of mometasone furoate 0.1 % to reduce high-grade acute radiation dermatitis in breast cancer patients receiving postmastectomy radiation [published correction appears in Int J Radiat Oncol Biol Phys 2018;102(1):231]. Int J Radiat Oncol Biol Phys 2018;101(2):325–33. DOI: 10.1016/j.ijrobp.2018.02.006

21. Kumar Soni S., Basu M., Agrawal P. et al. Evaluation of gamma radiation-induced biochemical changes in skin for dose assesment: a study on small experimental animals. Disaster med Public Health Prep 2019;13(2):197–202. DOI: 10.1017/dmp.2018.16


Review

For citations:


Balaeva D.A., Garyaev G.A., Ter-Ovanesov M.D., Romanov D.S., Gorchak Yu.Yu. Study of the use of La Roche-Posay Dermatological Laboratory skincare products for radiodermatitis prevention and treatment. Supportive Therapy in Oncology. 2024;1(2):14-22. (In Russ.) https://doi.org/10.17650/3034-2473-2024-1-2-14-22

Views: 151


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 3034-2473 (Print)
ISSN 3034-3178 (Online)